What symptom may indicate the progression into advanced Alzheimer's disease?

The symptom that may indicate the progression into advanced Alzheimer's disease is severe disorientation to time and place. In advanced stages of the disease, individuals often experience significant cognitive decline that manifests as confusion and an inability to recognize their surroundings or the time of day. This disorientation can severely impact their capacity to navigate their environment and even recognize familiar people or places, marking a clear indication of disease progression.

In contrast, frequent laughter, increased curiosity, and enhanced problem-solving skills are not typically associated with advanced Alzheimer's disease. These behaviors might suggest a level of cognitive functioning that is not characteristic of the advanced stages, where individuals often struggle with communication, memory, and understanding the world around them. Thus, severe disorientation to time and place serves as a critical milestone in recognizing the deterioration associated with advanced Alzheimer's disease.